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Outcomes using various accepted MACE composite endpoints in the Qsiva programme showed no increase in risk for any of these endpoints compared to placebo (hazard phentermine ratios <1 .
The applicant further cited supportive CV safety data from published results of clinical studies buying phentermine online generic phentermine otc phentermine 37.5 free trial can phentermine 37.5 with other sympathomimetic agents in other indications and from historical data with 2 .
Psychiatric safety – Although there was an phentermine zoloft does phentermine fail drug test phentermine diet doctors phentermine 37.5 high increase in reports of psychiatric and cognitive symptoms with the top-dose of Qsiva, the majority of these events were of mild severity, occurred early in treatment, resolved spontaneously or with discontinuation of study drug .
Reported rates phentermine for most CNS-related side effects were similar between the mid-dose and placebo .
Importantly, there were no increases in major depression diagnoses (by PHQ-9 questionaire), emergent antidepressant use, or suicidality (by C-SSRS questionaire) in phentermine the programme .
Teratogenic risk - Topiramate has been associated with phentermine an increased risk of teratogenesis; however, topiramate has been approved for 16 years and is currently in widespread use within the EU for migraine prophylaxis and epilepsy, which requires treatment at higher doses .
The Applicant addressed the need for effective contraception and the risk of teratogenesis in the adipex weight loss before and after photos phentermine quick results adipex and hcg diet together SmPC and the RMP, which included a detailed healthcare provider checklist as well as patient education card .
Furthermore, the applicant cited the example of topiramate as further evidence that this risk can be effectively mitigated by phentermine SmPC and RMP .

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